This Guide Book is designed to be a "genetic counselor in your pocket". The topics are central to a clinic specializing in reproduction. It will lay out the resources, textbooks, and websites to have readily available for interpretative needs. There will be designated focus on the recommended tests to offer individuals pregnant or thinking about becoming pregnant. These tests include maternal serum screening, cell-free DNA screening, carrier screening, amniocentesis, and chorionic villus sampling. This guide will take it a step further and discuss the considerations to make when deciding which labs to use for these recommended tests. Genetic testing is quickly evolving, so the latest technological advances will be discussed. Lastly, case examples will be discussed to provide context to the considerations that need to be made when ordering and interpreting these test results.